منابع مشابه
Function of the vitamin B6 group; mechanism of transamination.
The r&e of vitamin Bg in amino acid metabolism has been well established through enzyme studies (l-3) and by the substitution for various amino acids in growth studies (4-6). The coenzyme form, synthetic pyridoxal phosphate (7), functions as the coenzyme for amino acid decarboxylases (S-10), transaminases (2, 3), tryptophan formation (11)) and tryptophan breakdown by tryptophanase (12). The rea...
متن کاملFunction of the vitamin B6 group; pyridoxal phosphate (codecarboxylase) in transamination.
Vitamin Be has for some time been implicated in protein metabolism. More recently a specific function of pyridoxal in the coenzome of tyrosine decarboxylase has been found (l), and the discovery of this function extended to include amino acid decarboxylases in general (2, 3). All members of the vitamin Be group (pyridoxine, pyridoxal,” pyridoxamine) are converted into this coenzyme (termed code...
متن کاملVitamin B6 and arteriosclerosis.
In 1949, Rinehart and Greenberg reported that marked arteriosclerosis occurs in vitamin-B6-deficient monkeys. The present study investigates the relationship between vitamin B6 and arteriosclerosis and summarizes the results. I found that thrombogenesis, disorder of collagen metabolism and production of free radicals may be the processes that cause arteriosclerosis in human and experimental ani...
متن کاملHepatic Vitamin B6 Metabolism
nM. Thus, pyridloxal-P is the principal B6 vitaimer in plasma. Durinig pyridoxine stupplemiienitation, mealn plasnma levels of the B6 vitaimers anid pyridoxic acidl increasedl to 655±122 aindl 222±55 nM, respectively. The plasma content of pyridoxal-P aind( pyricloxic acidl increased 6-7-fold anid thatt of pyridoxal, 12-fold, but the pyridloxiine level did niot increase. Isolatedlhepatocytes, 1...
متن کاملPlasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
BACKGROUND Vitamin B(6) has attracted renewed interest because of its role in homocysteine metabolism and its possible relation to cardiovascular risk. We examined the plasma B(6) vitamers, pyridoxal 5'-phosphate (PLP), pyridoxal (PL), pyridoxine (PN), and 4-pyridoxic acid (4-PA) before and after vitamin B(6) supplementation. METHODS Patients (n = 90; age range, 38-80 years) undergoing corona...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1945
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)41666-8